Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 4, Pages 221-233Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.11.003
Keywords
fibroblast growth factor; fibroblast growth factor receptor; cell signalling; cancer
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Funding
- Breast Cancer Campaign
- Cancer Research UK
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Since its discovery 40 years ago, fibroblast growth factor (FGF) receptor (FGFR) signalling has been found to regulate fundamental cellular behaviours in a wide range of cell types. FGFRs regulate development, homeostasis, and repair and are implicated in many disorders and diseases; and indeed, there is extensive potential for severe consequences, be they developmental, homeostatic, or oncogenic, should FGF-FGFR signalling go awry, so careful control of the pathway is critically important. In this review, we discuss the recent developments in the FGF field, highlighting how FGFR signalling works in normal cells, how it can go wrong, how frequently it is compromised, and how it is being targeted therapeutically.
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