Journal
PEDIATRIC RESEARCH
Volume 75, Issue 3, Pages 376-380Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2013.238
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Funding
- National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH, Bethesda, MD) [5U01NS040069-05, 2R01NS040069-06A2]
- National Eye Institute (NIH) [1-R01-EY021820-01A1]
- National Institute of Child Health and Human Development (NIH) [5P30HD018655-28]
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Exposure to perinatal infection and inflammation is associated with an increased risk for neonatal brain damage and developmental disabilities. In this integrated mechanism review, we discuss evidence in support of the contention that the preterm newborn is capable of intermittent or sustained systemic inflammation (ISSI), which appears to contribute more to adverse neurodevelopmental outcomes in preterm infants than does shorter duration inflammation.
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