Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 10, Pages 623-632Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.07.002
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Funding
- National Institutes of Health [R01GM108722]
- Austrian Science Fund (FWF) fellowship [J3199-B09]
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Long noncoding RNA (IncRNA) is a pivotal factor regulating various aspects of genome activity. Genome regulation via DNA methylation and post-translational histone modifications is a well-documented function of IncRNA in plants, fungi, and animals. Here, we summarize evidence showing that IncRNA also controls chromatin structure, including nucleosome positioning and chromosome looping. We focus on data from plant experimental systems, discussed in the context of other eukaryotes. We explain the mechanisms of IncRNA-controlled chromatin remodeling and the implications of the functional interplay between noncoding transcription and several different chromatin remodelers. We propose that the unique properties of RNA make it suitable for controlling chromatin modifications and structure.
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