Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 6, Pages 320-329Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.02.001
Keywords
translational regulation; microRNA processing; microRNA function
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Funding
- Northeast Biodefense Center [U54-AI057158]
- Greenberg Medical Research Institute
- PHS [U54-AI057158, R01 AI091707]
- [R01AI057905]
- [R21AI100188]
- [R03AI097089]
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Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle. We review recent findings implicating a subset of ISGs in translational regulation of viral and host mRNAs. Translation inhibition is mediated either by binding to viral RNA or by disrupting physiological interactions or levels of the translation complex components. In addition, many of these ISGs localize to translationally silent cytoplasmic granules, such as stress granules and processing bodies, and intersect with the microRNA (miRNA)-mediated silencing pathway to regulate translation of cellular mRNAs.
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