Journal
TRENDS IN CELL BIOLOGY
Volume 25, Issue 4, Pages 241-248Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.10.006
Keywords
Myc; cancer; transcription
Categories
Funding
- Intramural NIH HHS [ZIA BC011465-03, Z99 CA999999] Funding Source: Medline
Ask authors/readers for more resources
Myc deregulation is a hallmark oncogenic event where overexpression of the transcription factor gives rise to numerous tumorigenic phenotypes. The complex consequences of Myc deregulation have prevented clear mechanistic interpretations of its function. A synthesis of recent experimental observations offers a consensus on the direct transcriptional function of Myc: when overexpressed, Myc broadly engages the established euchromatic cis-regulatory landscape of the cell, where the factor generally amplifies transcription. The level of Myc binding at target genes and the transcriptional output are differentially modulated by additional regulators, including Miz 1. Targeting Myc oncogenic activity will require an understanding of whether amplification promotes tumorigenesis and the consequences of amplification in tumors adapted to oncogenic Myc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available