Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 25, Issue 4, Pages 278-287Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2014.11.006
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Funding
- NHLBI NIH HHS [R01 HL119195, R01 HL110630, R01 HL112486, R01 HL123098, R01 HL086548, R01 HL097593] Funding Source: Medline
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Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal. (C) 2015 Elsevier Inc. All rights reserved.
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