Journal
PEDIATRIC RESEARCH
Volume 68, Issue 4, Pages 323-329Publisher
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e3181e6a068
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Funding
- NIH [R01 HD052953-01, HD057192]
- March of Dimes [6 FY08 260, 21 FY06 575]
- Egyptian Ministry of Higher Education
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This study is a retrospective, case control study involving 535 preterm infants examining the roles of sequence polymorphisms in genes that mediate host immune responses to bacterial infection in newborn infants. A total of 49 single nucleotide polymorphisms (SNPs) in 19 candidate genes including inflammatory cytokines (IL6, IL10, ILIB, and TNF), cytokine receptors (ILIRN), toll-like receptors (TLR2, TLR4, and TLR5), and cell surface receptors (CD14) were genotyped. Subjects were stratified into three groups (sepsis, suspected sepsis. and control). The data were analyzed using a family-based transmission disequilibrium test. We found that birth weight, gestational age, duration of rupture of membranes, and presence of clinical chorioamnionitis were strongly associated with sepsis. Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. Allelic variants in PLA2G2A and TLR2 were associated with Gram-positive infections, whereas IL10 was associated with Gram-negative infections (p < 0.05). We conclude allelic variations in PLA2G2A, TLR2, TLR5, and IL10 may moderate the predisposition to sepsis in preterm infants. (Pediatr Res 68: 323-329, 2010)
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