Journal
PEDIATRIC RESEARCH
Volume 68, Issue 2, Pages 91-98Publisher
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e3181e35a88
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Funding
- Canadian Institute of Health research
- Canada Research Chair
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Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced nephron number, is a common cause of pediatric renal failure and adult-onset disease. Genetic studies performed in humans and mutant mice have implicated a number of critical genes, in utero environmental factors and molecular mechanisms that regulate nephron endowment and kidney size. Here, we review current knowledge regarding the genetic contributions to renal hypoplasia with particular emphasis on the mechanisms that control nephron endowment in humans and mice. (Pediatr Res 68: 91-98, 2010)
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