Journal
TRENDS IN BIOTECHNOLOGY
Volume 33, Issue 6, Pages 362-369Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.03.008
Keywords
biopolymers; biomaterials; crosslinking; physiological conditions; stability; carboxylic acids
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Funding
- Ministry of Science and Technology, Department of Biotechnology, Government of India
- Center for Emerging Technologies at Jain University
- Fundamental Research Funds for the Central Universities [KLTST201404]
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Biomaterials made from proteins, polysaccharides, and synthetic biopolymers are preferred but lack the mechanical properties and stability in aqueous environments necessary for medical applications. Cross linking improves the properties of the biomaterials, but most crosslinkers either cause undesirable changes to the functionality of the biopolymers or result in cytotoxicity. Glutaraldehyde, the most widely used crosslinking agent, is difficult to handle and contradictory views have been presented on the cytotoxicity of glutaraldehyde-crosslinked materials. Recently, poly(carboxylic acids) that can crosslink in both dry and wet conditions have been shown to provide the desired improvements in tensile properties, increase in stability under aqueous conditions, and also promote cell attachment and proliferation. Green chemicals and newer crosslinking approaches are necessary to obtain biopolymeric materials with properties desired for medical applications.
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