Journal
TRENDS IN BIOTECHNOLOGY
Volume 33, Issue 2, Pages 65-79Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.10.006
Keywords
synthetic biology; protein engineering; antibody derivative; antibody mimetic; adoptive immunotherapy; autologous hematopoietic stem cell transplantation
Categories
Funding
- ERC [321381]
- INTERREG IV A.20
- Gutenberg Chair
- European Research Council (ERC) [321381] Funding Source: European Research Council (ERC)
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Humans have manipulated the immune system to dampen or boost the immune response for thousands of years. As our understanding of fundamental immunology and biotechnological methodology accumulates, we can capitalize on this combined knowledge to engineer biological devices with the aim of rationally manipulating the immune response. We address therapeutic approaches based on the principles of synthetic immunology that either ameliorate disorders of the immune system by interfering with the immune response, or improve diverse pathogenic conditions by exploiting immune cell effector functions. We specifically highlight synthetic proteins investigated in preclinical and clinical trials, summarize studies that have used engineered immune cells, and finish with a discussion of possible future therapeutic concepts.
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