Journal
PEDIATRIC RESEARCH
Volume 65, Issue 4, Pages 409-413Publisher
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e3181975efa
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Funding
- Health Research Council of New Zealand
- National Research Centre for Growth and Development
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Maternal undernutrition throughout pregnancy can have long-term effects on the health of adult offspring. Undernutrition around the time of conception alters growth, metabolism, and endocrinology of the sheep fetus. bill the impact on offspring after birth is largely unknown. We determined the effect of maternal periconceptional Undernutrition in sheep oil glucose tolerance in the offspring before and after puberty. Undernourished (UN) ewes were fed individually to maintain weight loss of 10-15%, bodyweight from 61 d before until 30 d after mating. 08-spring (24 UN, 30 control) underwent an i.v. glucose tolerance test at 4 and 10 mo of awe. Glucose tolerance was similar in both groups at 4 mo. Insulin area under the curve increased by 33% between 4 and 10 mo (101 +/- 8 versus 154 +/- 12 ng . min . mL(-1), p < 0.0001). At 10 mo. UN offspring had a 10% greater glucose area under the curve than controls (809 +/- 22 versos 712 +/- 20 mM . min, p < 0.01), a reduced first phase insulin response (p = 0.003) which was particularly apparent in females and in singletons, and a decreased insulin:glucose ratio (p = 0.01). We conclude that maternal undernutrition around the time of conception results in impaired glucose tolerance in postpubertal offspring. (Pediatr Res 65: 409-413, 2009)
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