Journal
PEDIATRIC RESEARCH
Volume 66, Issue 4, Pages 357-363Publisher
NATURE PUBLISHING GROUP
DOI: 10.1203/PDR.0b013e3181b0cbd8
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Funding
- Genome Canada through the Ontario Genomics Institute
- Canadian Institutes for Health Research
- Canadian Institutes for Advanced Research
- McLaughlin Centre for Molecular Medicine
- Canadian Foundation for Innovation
- Ontario Ministry of Research and Innovation
- Hospital for Sick Children Foundation
- MRC
- GlaxoSmithKIine
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Momentum around the era of genomic medicine is building, and with it, anticipation of the benefits that whole genome analysis (personalized or individualized genomics) will bring for the provision of health care. These technologies have the potential to revolutionize genetic diagnosis; however, the expansive data generated can lead to complex or unexpected findings, sometimes complicating clinical utility and patient benefit. Here, we use our experience with whole genome scanning microarrays, an early instance of whole genome analysis already in clinical use, to highlight fundamental challenges raised by these technologies and to discuss their medical, ethical, legal and social implications. We discuss issues that physicians and healthcare professionals will face, in particular, as the resolution of testing further increases toward full genome sequence determination. We emphasize that addressing these issues now, and starting to evolve our healthcare systems in response, will be pivotal in avoiding harms and realizing the promise of these new technologies. (Pediatr Res 66: 357-363, 2009)
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