Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 40, Issue 5, Pages 265-274Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.03.006
Keywords
gene expression; translation; protein synthesis; decoding; ribosome; mRNA reading frame maintenance
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Funding
- Max Planck Society
- Deutsche Forschungsgemeinschaft
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Programmed -1 ribosomal frameshifting (-1PRF) is an mRNA recoding event commonly utilized by viruses and bacteria to increase the information content of their genomes. Recent results have implicated -1PRF in quality control of mRNA and DNA stability in eukaryotes. Biophysical experiments demonstrated that the ribosome changes the reading frame while attempting to move over a slippery sequence of the mRNA - when a roadblockformed by a folded downstream segment in the mRNA stalls the ribosome in a metastable conformational state. The efficiency of -1PRF is modulated not only by cis-regulatory elements in the mRNA but also by transacting factors such as proteins, miRNAs, and antibiotics. These recent results suggest a molecular mechanism and new important cellular roles for -1PRF.
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