Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 40, Issue 4, Pages 211-220Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.02.004
Keywords
X-ray crystallography; cooperativity; c-di-AMP riboswitch; glycine riboswitch; FMN riboswitch; bacteriophage phi 29 pRNA
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Funding
- National Heart, Lung, and Blood Institute, National Institutes of Health (NIH)
- Lenfant Biomedical Postdoctoral Fellowship
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Many proteins associate into symmetric multisubunit complexes. Structural analyses suggested that, by contrast, virtually all RNAs with complex 3D structures function as asymmetric monomers. Recent crystal structures revealed that several biological RNAs exhibit global symmetry at the level of their tertiary and quaternary structures. Here we survey known examples of global RNA symmetry, including the true quaternary symmetry of the bacteriophage phi 29 prohead RNA (pRNA) and the internal pseudosymmetry of the single-chain flavin mononucleotide (FMN), glycine, and cyclic di-AMP (c-di-AMP) riboswitches. For these RNAs, global symmetry stabilizes the RNA fold, coordinates ligand-RNA interactions, and facilitates association with symmetric binding partners.
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