Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 40, Issue 4, Pages 233-242Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.02.006
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Funding
- NIH [GM080670]
- American Cancer Society [RSG-12-013-01-CCG]
- Leukemia and Lymphoma Society Scholar Award
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Sumoylation has important roles during DNA damage repair and responses. Recent broad-scope and substrate-based studies have shed light on the regulation and significance of sumoylation during these processes. An emerging paradigm is that sumoylation of many DNA metabolism proteins is controlled by DNA engagement. Such 'on-site modification' can explain low substrate modification levels and has important implications in sumoylation mechanisms and effects. New studies also suggest that sumoylation can regulate a process through an ensemble effect or via major substrates. Additionally, we describe newtrends in the functional effects of sumoylation, such as bi-directional changes in biomolecule binding and multilevel coordination with other modifications. These emerging themes and models will stimulate our thinking and research in sumoylation and genome maintenance.
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