Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 40, Issue 8, Pages 446-455Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.05.006
Keywords
cytochrome c; mitochondria; heme attachment; holocytochrome c synthase
Categories
Funding
- National Institutes of Health (NIH) [GM47909]
- NIH [F32GM108278]
Ask authors/readers for more resources
Cytochromes c (cyt c) and c(1) are heme proteins that are essential for aerobic respiration. Release of cyt c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS)., which is also necessary for the import of apocytochrome c (apocyt c). Thus, HCCS affects cellular levels of cyt c, impacting mitochondrial physiology and cell death. Here, we review the mechanisms of HCCS function and the roles of heme and residues in the CXXCH motif. Additionally, we consider concepts emerging within the two prokaryotic cytochrome c biogenesis pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available