Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 40, Issue 3, Pages 130-140Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2015.01.004
Keywords
cancer metabolism; tumor metabolism; cell proliferation; nutrient availability
Categories
Funding
- Burroughs Wellcome Fund
- Lustgarten Foundation
- American Association for Cancer Research
- National Cancer Institute
- [F30 CA183474]
Ask authors/readers for more resources
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole-body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available