Journal
PEDIATRIC PULMONOLOGY
Volume 45, Issue 11, Pages 1111-1120Publisher
WILEY
DOI: 10.1002/ppul.21296
Keywords
probiotics; clinical trial; allergic rhinitis; asthma
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Funding
- National Science Council, Taiwan [NSC 96 2314-B-006-027-MY3]
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Previous studies have suggested that probiotic administration may have therapeutic and/or preventive effects on atopic dermatitis in infants however its role in allergic airway diseases remains controversial To determine whether daily supplementation with specific Lactobacillus gasseri A5 for 8 weeks can improve the clinical symptoms and immunoregulatory changes in school children suffering from asthma and allergic rhinitis (AR) We conducted a randomized double blind placebo controlled study on school children (age 6-12 years) with asthma and AR The eligible study subjects received either L gasseri A5 (n = 49) or a placebo (n = 56) daily for 2 months Pulmonary function tests were performed and the clinical severity of asthma and AR was evaluated by the attending physicians in the study period Diary cards with records of the day and nighttime peak expiratory flow rates (PEFR) symptoms of asthma and AR scores of the patients were used for measuring the outcome of the treatment Immunological parameters such as the total IgE and cytokine production by the peripheral blood mononuclear cells (PBMCs) were determined before and after the probiotic treatments Our results showed the pulmonary function and PEFR increased significantly and the clinical symptom scores for asthma and AR decreased in the probiotic treated patients as compared to the controls Further there was a significant reduction in the TNF alpha IFN gamma IL 12 and IL 13 production by the PBMCs following the probiotic treatment In conclusion probiotic supplementation may have clinical benefits for school children suffering from allergic airway diseases such as asthma and AR Pediatr Pulmonol 2010, 45 1111-1120 (C) 2010 Wiley Liss Inc
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