Journal
PEDIATRIC NEUROLOGY
Volume 42, Issue 4, Pages 239-242Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pediatrneurol.2009.08.011
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Recent advances in radioimaging and immunocytological techniques have enhanced investigations of neuro-metabolites and axons, giving rise to renewed interest in human white-matter disorders. A strong correlation between axonal loss and disability in some demyelination diseases (e.g., multiple sclerosis) led to several studies examining the mechanisms of axonal damage. We review the relationship between demyelination, axon loss, and neurologic progression, and the role of advanced neuroimaging in children with different types of leukodystrophies, i.e., X-linked adrenoleukodystrophy, metachromatic leukodysrtophy, Krabbe's disease, Pelizaeus-Merzbacher disease, and Alexander's disease. (C) 2010 by Elsevier Inc. All rights reserved.
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