Journal
PEDIATRIC NEUROLOGY
Volume 39, Issue 6, Pages 392-398Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pediatrneurol.2008.07.019
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- NCRR NIH HHS [RR-17672-01] Funding Source: Medline
- NINDS NIH HHS [K12NS048856] Funding Source: Medline
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Few studies have compared gastrointestinal problems in children with an autism spectrum disorder with and without a history of language regression. A cross-sectional study was conducted with structured interviews in 100 children with autism spectrum disorder, using a gastrointestinal questionnaire and a familial autoimmune questionnaire. By parental report, children with language regression more frequently exhibited an abnormal stool pattern (40% vs 12%, P = 0.006) and had an increased family history of celiac disease or inflammatory bowel disease (24% vs 0%, P = 0.001) and of rheumatoid arthritis (30% vs 11%, P = 0.03). Among 35 children with a family history of autoimmune disease, an abnormal stool pattern was reported more frequently in those with language regression (78% vs 15%, P = 0.001) than in those without. An association was observed between children with language regression, a family history of autoimmune disease, and gastrointestinal symptoms. Additional studies are needed to examine a possible shared auto-immune process. (C) 2008 by Elsevier Inc. All rights reserved.
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