Journal
PEDIATRIC NEPHROLOGY
Volume 28, Issue 1, Pages 5-11Publisher
SPRINGER
DOI: 10.1007/s00467-012-2138-4
Keywords
Alport syndrome; Proteinuria; Angiotensin-converting enzyme inhibitor; Angiotensin receptor blocker; Aldosterone inhibitor
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Funding
- Alport Syndrome Foundation
- Association pour l'Information et la Recherche sur les Maladies Renales Genetiques (AIRG)
- KfH Foundation Preventive Medicine (Fritz-Scheler Stipendium of the German Society of Nephrology)
- German Ministry of Education and Research
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We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin-angiotensin-aldosterone system.
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