Journal
PEDIATRIC NEPHROLOGY
Volume 28, Issue 6, Pages 843-854Publisher
SPRINGER
DOI: 10.1007/s00467-012-2246-1
Keywords
Transcription factor; Phosphatase; Sensory placode; Specification of metanephric mesenchyme; Induction of ureteric bud; Ureter; Cell proliferation; Cell survival
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Funding
- National Institutes of Health [NIH RO1 DC005824, DK064640]
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Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.
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