Journal
PEDIATRIC NEPHROLOGY
Volume 28, Issue 4, Pages 605-610Publisher
SPRINGER
DOI: 10.1007/s00467-012-2377-4
Keywords
Vitamin D; Inflammation; Chronic kidney disease; Cardiovascular disease; Children
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Recent studies have provided evidence for an important role of vitamin D deficiency in the pathogenesis of cardiovascular disease (CVD) in the general population, and of an association with markers of inflammation. Vitamin D deficiency, defined by low serum levels of 25-hydroxyvitamin D, is especially prevalent in patients with chronic kidney disease (CKD). Chronic low-grade inflammation is a hallmark of CKD and has been disclosed as one important factor contributing to the progression of CKD and a high cardiovascular comorbidity. This review highlights clinical and experimental studies that could potentially explain a link between vitamin D and inflammation. Whether correction of vitamin D deficiency has beneficial effects on markers of inflammation and cardiovascular outcome should be investigated by controlled clinical trials.
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