Journal
PEDIATRIC NEPHROLOGY
Volume 23, Issue 9, Pages 1395-1398Publisher
SPRINGER
DOI: 10.1007/s00467-008-0818-x
Keywords
bone morphogenic protein (BMP); chronic kidney disease (CKD); fibroblasts; epithelial-mesenchymal transition (EMT); fibrogenesis; scarring
Categories
Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK061688, R01DK055001, K08DK074558, R01DK062987] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA013913] Funding Source: NIH RePORTER
- NIAAA NIH HHS [R01 AA013913, AA13913] Funding Source: Medline
- NIDDK NIH HHS [R01 DK061688, K08 DK074558, DK55001, DK61688, R01 DK055001, DK62987] Funding Source: Medline
Ask authors/readers for more resources
Bone morphogenic protein-7 (BMP7) is a morphogen that is important for kidney development and which is also an integral part of the kidney's physiological response to repair of acute kidney injury. Several studies demonstrate that preexisting renal BMP7 pathways can be utilized by administering recombinant BMP7 to protect the kidney in experimental models of chronic kidney disease (CKD). Effectiveness of recombinant BMP7 in animal studies raises the possibility that the BMP7 pathway could be equally utilized to treat patients with CKD and interstitial fibrosis. However, regulation of BMP7 activity in the kidney is complex. BMP7 activity in the kidney is not only determined by availability of BMP7 itself, but also by a balance of agonists, such as Kielin/chordin-like protein (KCP) or BMP receptors, and antagonists including gremlin, noggin, or uterine sensitization-associated gene-1 (USAG-1). Presence of BMP7 agonists and antagonists has to be considered when recombinant BMP7 is supplemented to treat injured kidneys. Here we summarize recent insights into the role of BMP7 in acute and chronic kidney injury and discuss the implications for future directions of antifibrotic therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available