Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 33, Issue 4, Pages E99-E105Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000000237
Keywords
pediatric; JC virus; granule cell neuron; HIV; progressive multifocal leukoencephalopathy
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Funding
- National Institute of Allergy and Infectious Diseases [T32 AI 007433]
- Agency for Healthcare Research and Quality [T32 HS 019485-01]
- National Institute of Child Health and Human Development [T32 HD 055148-02, R56 NS 041198, R01 NS 047029, R01 NS 074995, K24 NS 060950]
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Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.
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