Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 33, Issue 5, Pages 495-498Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000000143
Keywords
zidovudine; pharmacokinetics; HIV; children; Africa
Categories
Funding
- UK Medical Research Council
- UK Department for International Development (DfID)
- GlaxoSmithKline
- Medical Research Council [MC_EX_G0300400, MC_U122886353] Funding Source: researchfish
- National Institute for Health Research [CL-2009-13-005] Funding Source: researchfish
- MRC [MC_U122886353, MC_EX_G0300400] Funding Source: UKRI
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Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC(0-12h) was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.
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