Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 31, Issue 3, Pages 306-308Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3182458289
Keywords
BCG; infant mortality; neonatal mortality; nonspecific effects of vaccines
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Funding
- EU [ICA4-CT-2002-10053]
- March of Dimes
- Danish National Research Foundation
- European Research Council (ERC) [243149]
- DANIDA
- Novo Nordisk Foundation
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A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guerin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.
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