Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 31, Issue 7, Pages 771-773Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3182575e6a
Keywords
dengue; pentoxifylline; dengue hemorrhagic fever; inflammatory cytokines; plasma leakage
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The current treatment for dengue hemorrhagic fever largely consists of supportive care. The drug pentoxifylline has been shown to blunt the proinflammatory actions of tumor necrosis factor-alpha, a key mediator of dengue hemorrhagic fever. We performed a pilot study evaluating pentoxifylline's effect on 55 children with dengue hemorrhagic fever. We believe our findings support the existing literature on its potential use in severe infection.
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