Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 30, Issue 1, Pages S48-S53Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3181fefd90
Keywords
RotaTeq; Rotarix rotavirus; strain; surveillance; Australia
Categories
Funding
- Australian Commonwealth Department of Health and Aging
- Commonwealth Serum Laboratories (Melbourne, Australia)
- National Health and Medical Research Council of Australia [607347]
- GlaxoSmithKline
- Commonwealth Serum Laboratories
- Australian Government Department of Health and Ageing
- GSK Biologicals (Melbourne, Australia)
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Background: Rotavirus vaccines, RotaTeq and Rotarix, were introduced into the Australian National Immunization Program on July 1, 2007. The simultaneous introduction in different Australian states and territories provides a unique opportunity to compare the affect of each vaccine on the types of circulating rotavirus strains. This report describes the rotavirus genotypes responsible for the hospitalization of children during the first 2-year period after vaccine introduction. Methods: A total of 764 rotavirus-associated diarrheal cases were collected from children presenting to hospital in 10 Australian centers. Rotavirus genotype was determined using reverse transcription polymerase chain reaction assays. Results: G1P[8] was the dominant genotype nationally (52%), followed by G2P[4] (19.8%), G9P[8] (12.2%), and G3P[8] (11%). Differences in the prevalence rates of G2P[4] and G3P[8] were seen in the various states. G2P[4] strains were more prevalent in states using Rotarix, whereas G3P[8] strains were more prevalent in states using RotaTeq. Conclusions: Differences in rotavirus genotypes were observed across Australia, which suggest that different immune pressures are exerted by the different vaccines, but do not necessarily imply lack of protection by either vaccine. These differences may simply be related to the variation that can occur because of natural annual fluctuation in rotavirus strain prevalence.
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