Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 30, Issue 10, Pages 900-901Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e31821ffe43
Keywords
influenza; heterosubtypic; heterotypic; homosubtypic; children
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Funding
- MedImmune
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The effect of subtype-specific influenza illness in young children on the probability of influenza illness in the following year was analyzed for placebo recipients in four 2-year vaccine efficacy studies. There was evidence of homosubtypic protection but no evidence of heterosubtypic protection; however, a moderate-to-low level of heterosubtypic protection could not be ruled out. This analysis supports previous observations that children do not develop lasting, clinically significant heterosubtypic protection after influenza illness.
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