Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 29, Issue 1, Pages 79-82Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e3181b21040
Keywords
lopinavir; therapeutic drug monitoring; HIV; children; generic drug tablets
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Funding
- National Health Security Office (NHSO), Thailand
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Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (C-trough) was 6.7 (5.0-9.9) mg/L. All the children had C-trough>1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.
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