4.5 Article

MATERNALLY DERIVED ANTIBODIES AGAINST BORDETELLA PERTUSSIS ANTIGENS PERTUSSIS TOXIN AND FILAMENTOUS HEMAGGLUTININ IN PRETERM AND FULL TERM NEWBORNS

Journal

PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 28, Issue 5, Pages 443-445

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e318193ead7

Keywords

immunity; maternally acquired; antibodies; Bordetella pertussis; ELISA; infant; premature

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We measured IgG-anti-pertussis toxin and -IgG-anti-filamentous hemagglutinin antibody values in 43 full term and 34 preterm infants and 79 mothers. Antibody values were generally low and mean values were higher in full term than preterm infants. Transfer ratios increased with gestational age of the newborns. Based on these findings, maternal and neonatal immunization strategies should be considered to protect young infants from pertussis.

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