Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 27, Issue 10, Pages 946-948Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0b013e318175d85c
Keywords
varicella; Oka; acyclovir; resistance; immunosuppressed; neuroblastoma
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Funding
- Public Health Service [NOI-AI-30049]
- NIH NIAID
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A 21-month-old girl with neuroblastoma developed chronic verrucous Oka strain varicella-zoster infection during chemotherapy. Virus isolated from the patient demonstrated high-level acyclovir resistance, and its thymidine kinase had no in vitro enzymatic activity. After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation. This is only the second reported case of resistant varicella zoster virus caused by Oka strain virus.
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