Journal
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Volume 26, Issue 7, Pages 526-532Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010903044540
Keywords
high-dose methylprednisolone; immune thrombocytopenic purpura; intravenous immunoglobulin; vaccination
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The authors investigated demographics, clinical and laboratory features, treatment responses, and outcomes of 93 children (median age 5 years) admitted for idiopathic thrombocytopenic purpura (ITP). The therapy responses of high-dose methylprednisolone (HDMP) (n = 77) and intravenous immunoglobulin (IVIG) (n = 10) treatments were similar. None of the patients with hemorrhage died. Fifteen patients (16.1%) had progressed into chronic ITP. Seven infants had a probable relationship with vaccination; none of these infants progressed into chronic ITP. In conclusion, the overall prognosis in childhood ITP is good. The therapy responses of HDMP and IVIG treatments are similar. Also, ITP cases who havw vaccination history have a benign course.
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