Journal
PEDIATRIC EMERGENCY CARE
Volume 27, Issue 1, Pages 43-45Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PEC.0b013e3182045f76
Keywords
bupropion; ECMO; seizures; aspiration pneumonia; hypotension
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An 11-month-old male infant presented with history of bupropion ingestion (750 mg/kg). He developed seizures, respiratory failure, and severe hypotension with metabolic acidosis refractory to inotropic support. The patient received mechanical ventilation, intralipids, phenytoin, inotropic support (dopamine, norepinephrine, and epinephrine), and extracorporeal membrane oxygenation (ECMO). Inotropes were weaned upon initiation of ECMO and discontinued 66 hours after ingestion. Total ECMO duration was 71 hours. The patient was extubated on hospital day 8 and has not had any neurological sequelae upon 12-month follow-up examinations. We report for the first time successful use of ECMO after ingestion of a potentially fatal dose of bupropion.
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