Journal
PEDIATRIC DIABETES
Volume 16, Issue 1, Pages 10-15Publisher
WILEY
DOI: 10.1111/pedi.12158
Keywords
adolescent; cystic fibrosis; diabetes mellitus; insulin infusion system; young adult
Categories
Funding
- German Federal Ministry of Education and Research [FKZ: 01GI1106]
- European Foundation
- Diabetes Research for Patient Stratification consortium (DIRECT)
- European Foundation for the Study of Diabetes [AZ Macrov 2014_2] Funding Source: researchfish
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BackgroundIn type 1 diabetes (T1D), the use of continuous subcutaneous insulin infusion (CSII) has increased steadily in the last years. Compared with conventional insulin injection regimes, major advantages might be a nearly physiological insulin secretion, lower rates of hypoglycemia, higher flexibility in daily life, and increased quality of life. Data on CSII in cystic fibrosis-related diabetes (CFRD) are scarce. ObjectiveTo analyze current use of insulin pumps in CFRD and compare demographics of pump-treated patients between CFRD and T1D. MethodsData from the prospective German/Austrian diabetes patient registry on insulin-treated patients with either CFRD (n = 515) or T1D (n = 43 165) aged >10 yr at manifestation of diabetes were analyzed. ResultsA total of 4.1% (n = 21) of CFRD and 17.7% (n = 7647) of T1D patients received insulin pump treatment within the recent year of care (p < 0.001). Pump-treated patients with CFRD had a significantly shorter duration of diabetes [median (Q(1); Q(3)): 5.8 (2.9; 9.5) vs. 7.8 (4.3; 20.4) yr, p = 0.026] and tended to be younger [22.0 (18.2; 30.1) vs. 24.9 (17.3; 45.9) yr] than pump-treated T1D patients. Age at initiation of CSII seemed to be lower in CFRD [19.2 (16.5; 29.2) vs. 23.3 (14.8; 43.5) yr]. Insulin pump therapy was used slightly more often in male CFRD patients than females (4.7 vs. 3.6%), whereas in T1D the opposite was observed (14.9 vs. 21.2%, p < 0.001). Discontinuation rate of CSII was higher in CFRD than T1D (30.0 vs. 12.7%, p = 0.005). ConclusionsDespite potential advantages, insulin pump therapy was rarely used among adolescent and young adult CFRD patients.
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