Journal
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Volume 139, Issue 10, Pages 1308-1313Publisher
COLL AMER PATHOLOGISTS
DOI: 10.5858/arpa.2013-0345-RS
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The majority of patients with acute promyelocytic leukemia (APL) manifest the t(15; 17)(q24.1;q21.2) translocation; however, a minor but significant proportion of patients with APL harbor complex, cryptic, or variant translocations, which typically involve RARA. With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenotypic features as classic APL. Study of the variant forms of APL not only gives insight into the pathogenesis of APL but also allows us to understand the mechanism of retinoid therapy. It is important to identify these cryptic and variant translocations because certain variants, including ZBTB16/RARA and STAT5B/RARA, are resistant to treatment with all-trans retinoic acid, arsenic trioxide, and anthracyclines.
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