4.1 Article Proceedings Paper

Epicardial Control of Myocardial Proliferation and Morphogenesis

Journal

PEDIATRIC CARDIOLOGY
Volume 30, Issue 5, Pages 617-625

Publisher

SPRINGER
DOI: 10.1007/s00246-009-9391-8

Keywords

Compact zone; Epicardium; Heart development

Funding

  1. NHLBI NIH HHS [HL070123] Funding Source: Medline

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The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.

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