Journal
PEDIATRIC CARDIOLOGY
Volume 30, Issue 5, Pages 617-625Publisher
SPRINGER
DOI: 10.1007/s00246-009-9391-8
Keywords
Compact zone; Epicardium; Heart development
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Funding
- NHLBI NIH HHS [HL070123] Funding Source: Medline
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The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.
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