Journal
PEDIATRIC CARDIOLOGY
Volume 30, Issue 5, Pages 651-658Publisher
SPRINGER
DOI: 10.1007/s00246-008-9366-1
Keywords
Cardiomyocytes; c-Kit; Terminal differentiation
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Funding
- NHLBI NIH HHS [R01 HL079040-04, R01 HL079040, R01 HL079040-03, R01 HL079040-05, R01 HL079040-02, R01 HL079040-01A1] Funding Source: Medline
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Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically indistinguishable from those of wild type mice, except that they are capable of proliferation in vivo after acute pressure overload. This review explores the idea that postnatal cardiomyocyte differentiation and cell cycle withdrawal are distinct processes and that terminal differentiation may not simply be due to altered expression of genes that regulate the cell cycle but could involve c-kit induced epigenetic change.
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