Journal
PEDIATRIC CARDIOLOGY
Volume 31, Issue 3, Pages 335-341Publisher
SPRINGER
DOI: 10.1007/s00246-009-9605-0
Keywords
Abnormal heart formation; Cardiac NK-2 genes; Cardiac NK-2 transcription factors; Congenital heart disease; Early heart development
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Funding
- NICHD NIH HHS [R01 HD054356, R01 HD054356-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM069944, R01 GM069944-05A2] Funding Source: Medline
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The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart (dorsal vessel), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.
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