4.4 Article

Physical Activity and Cardiovascular Risk Factors in Childhood Cancer Survivors

Journal

PEDIATRIC BLOOD & CANCER
Volume 62, Issue 2, Pages 305-310

Publisher

WILEY
DOI: 10.1002/pbc.25276

Keywords

epidemiology; late effects; long-term survival; pediatric oncology

Funding

  1. National Institutes of Health [T32 CA099936, K05 CA157439, NCI/NIDDK R01CA113930, GCRC M01-RR00400, CTSA UL1TR000114]
  2. Children's Cancer Research Fund Hodder Chair

Ask authors/readers for more resources

Background. Childhood cancer survivors (CCS) are at high risk of developing treatment-related late effects, including cardiovascular disease and diabetes. Late effects can be exacerbated by low physical activity (PA) levels. Relationships between PA and cardiovascular risk factors during childhood have not been well described in CCS. Procedure. PA and cardiovascular risk factors were measured cross-sectionally in 319 CCS and 208 sibling controls aged 9-18 years. Comparisons between CCS and controls and associations of outcomes with PA (dichotomized at 60 min/day or treated as continuous) were performed with linear regression. Results. Among CCS, the high PA group had lower percent fat mass (24.4% vs. 29.8%, P< 0.0001), abdominal subcutaneous fat (67.9 vs. 97.3cm(3), P = 0.0004), and abdominal visceral fat (20.0 vs. 24.9cm(3), P = 0.007) and greater lean body mass (41.3 vs. 39.5 kg, P = 0.009) than the low PA group. Comparing CCS to controls, differences in waist circumference (P-interaction = 0.04), percent fat mass (P-interaction = 0.04), and abdominal subcutaneous (P-interaction = 0.02) and visceral (P-interaction = 0.004) fat between low and high PA groups were greater in CCS than controls, possibly due to greater overall adiposity in CCS. Conclusions. High PA in CCS resulted in an improved cardiovascular profile, consisting primarily of lower fat mass and greater lean mass, similar to that observed in controls. This suggests interventions directed to increase PA in CCS may reduce the risk of future cardiovascular disease. (C) 2014 Wiley Periodicals, Inc.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available