Journal
PEDIATRIC BLOOD & CANCER
Volume 60, Issue 2, Pages 326-328Publisher
WILEY PERIODICALS, INC
DOI: 10.1002/pbc.24319
Keywords
Epstein-Barr virus; hemophagocytic lymphohistiocytosis; T lymphocyte
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Funding
- Japan Society for the Promotion of Science [C-23591564]
- Grants-in-Aid for Scientific Research [23591564, 24791055, 24659493] Funding Source: KAKEN
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EpsteinBarr virus (EBV) is the most common infectious cause of non-genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV-infected lymphocytes and immune dysfunction in EBV-associated HLH, blood samples from a 6-year-old boy were longitudinally analyzed using molecular techniques. EBV-positive lymphocytes were detected as CD5+, CD8+, and/or HLA DR+ lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8+ cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case. Pediatr Blood Cancer 2013;60:326328. (c) 2012 Wiley Periodicals, Inc.
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