Journal
PEDIATRIC BLOOD & CANCER
Volume 60, Issue 1, Pages 146-148Publisher
WILEY
DOI: 10.1002/pbc.24284
Keywords
cancer genetics; mesothelioma; rare tumors
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Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted. Pediatr Blood Cancer 2013;60:146-148. (C) 2012 Wiley Periodicals, Inc.
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