Journal
PEDIATRIC BLOOD & CANCER
Volume 59, Issue 5, Pages 939-940Publisher
WILEY
DOI: 10.1002/pbc.24171
Keywords
hepatoblastoma; new agents; pediatric oncology
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We report the use of sorafenib and bevacizumab in combination for a patient with recurrent metastatic hepatoblastoma (HB). This combination demonstrated activity against our patient's refractory HB that had been extensively treated with multiple prior chemotherapeutic regimens. The patient had stabilization of radiographic disease coupled with an 83% decrease in his alpha-fetoprotein level. Given the response in this setting and the paucity of other available options, consideration could be given to using this combination as therapy in patients with recurrent HB who have failed more traditional agents. Pediatr Blood Cancer 2012; 59: 939940. (C) 2012 Wiley Periodicals, Inc.
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