Journal
PEDIATRIC BLOOD & CANCER
Volume 58, Issue 4, Pages 519-524Publisher
WILEY PERIODICALS, INC
DOI: 10.1002/pbc.23201
Keywords
acute myeloid leukemia; chloroma; myeloid sarcoma
Categories
Funding
- Chair's Grant [U10 CA98543, U10 CA98413]
Ask authors/readers for more resources
Background Extramedullary leukemia (EML) is common in pediatric acute myeloid leukemia (AML) and occurs as leukemia cells within the cerebrospinal fluid (CSF) or as a solid tumor (myeloid sarcomaMS). The effect of MS on survival is unknown. Methods. Patients on CCG protocols 2861, 2891, 2941, and 2961 being treated for AML with intensive-timing chemotherapy were classified for the presence of EML (CSF leukemia, CNS-MS, orbital- MS, or non-CNS MS). CSF leukemia was classified as CNS3 (> 5 WBC in the CSF with blasts) and non-CSF leukemia as CNS1/ 2 (< 5 WBC in the CSF with or without blasts). Characteristics and outcomes of these patients were compared. Results. Of the 1,459 total patients, 1,206 (82%) had no EML, 154 (11%) had CSF leukemia, 19 (1%) had CNS-MS, 23 (2%) had orbital-MS, and 57 (4%) had non-CNS MS. The CR rate was significantly higher in patients with orbital-MS and CNS-MS than in those with non-MS and non-CNS MS (96% and 95% vs. 78% and 78%, P 0.034). Patients with orbital-MS and CNS-MS had significantly higher overall survival than patients with non-CNS MS (92% and 73% vs. 38%, P < 0.001), CNS3 patients (92% and 73% vs. 51, P < 0.001), and CNS1/ 2 patients (92% and 73% vs. 50%, P < 0.001). Patients with orbitalMS had a significantly lower relapse rate. Conclusion. Patients with MS involving orbital and CNS sites had a significantly better survival than patients with non-CNS MS, with CSF leukemia, or with no EML. Pediatr Blood Cancer 2012; 58: 519-524. (C) 2011 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available