Journal
PEDIATRIC BLOOD & CANCER
Volume 58, Issue 5, Pages 815-818Publisher
WILEY
DOI: 10.1002/pbc.23290
Keywords
developmental therapeutics; Notch; preclinical testing
Categories
Funding
- National Cancer Institute [NO1-CM-42216, CA21765, CA16058, CA108786]
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RO4929097 is a potent and selective inhibitor of ?-secretase and as a result is able to inhibit Notch pathway signaling. The activity of RO4929097 was evaluated against the in vivo panels of the Pediatric Preclinical Testing Program (PPTP). RO4929097 induced significant differences in event-free survival (EFS) distribution compared to control in 6 of 26 (23%) of the evaluable solid tumor xenografts and in 0 of 8 (0%) of the evaluable ALL xenografts. The most consistent tumor growth delay effects were noted in the osteosarcoma panel. RO4929097 at the dose and schedule evaluated demonstrated little antitumor activity against childhood cancer xenografts. Pediatr Blood Cancer 2012; 58: 815818. (C) 2011 Wiley Periodicals, Inc.
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