Journal
PEDIATRIC BLOOD & CANCER
Volume 54, Issue 3, Pages 476-479Publisher
WILEY
DOI: 10.1002/pbc.22298
Keywords
mTOR; rapamycin; sirolimus; subependymal giant cell astrocytoma; tuberous sclerosis complex
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Tuberous sclerosis complex (TSC) is associated with hamartomatous growths including subependymal giant cell astrocytomas (SEGAs). Since chemo-radiation therapies offer scant benefit, oncologists had traditionally been little involved in managing SEGAs. Recent evidence demonstrating rapamycin efficacy in adults and children with TSC-associated tumors foresee a practice change. We summarize our institutional experience and literature review that highlight potential benefits and hazards of rapamycin therapy, for TSC patients with SEGA, and other syndromal brain tumors. Pediatr Blood Cancer 2010;54:476-479. (C) 2009 Wiley-Liss, Inc.
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