Journal
PEDIATRIC BLOOD & CANCER
Volume 54, Issue 4, Pages 644-646Publisher
WILEY
DOI: 10.1002/pbc.22376
Keywords
germinoma; high dose chemotherapy; intracranial germ cell tumors; non-germinomatous germ cell tumors
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This review of the experience of high dose chemotherapy in patients with recurrent or refractory intracranial germ cell tumor confirms that sustained tumor control can be achieved with this modality both in germinoma and non-germinomatous germ cell tumors. Data from cooperative groups in Europe and North America suggest that the success rate is higher among patients with recurrent germinoma. The role of adjuvant radiation in that context remains unclear. These promising results have led some cooperative groups to incorporate in their protocols a high dose chemotherapy component for newly diagnosed patients with high-risk features or poor response to initial chemotherapy. Pediatr Blood Cancer 2010,54 644-646 (C) 2010 Wiley-Liss, Inc
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