Journal
PEDIATRIC BLOOD & CANCER
Volume 55, Issue 3, Pages 580-582Publisher
WILEY-LISS
DOI: 10.1002/pbc.22584
Keywords
2-locus-mismatched transplantation; cord blood transplantation; Fanconi anemia; graft failure; second stem cell transplantations
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Funding
- King Hussein Cancer Foundation
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A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stern cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT. A sustained hematological engraftment was achieved at 9 days post-second HSCT. At 15 months post-second HSCT: the patient demonstrated normal blood counts, sustained donor chimerism, and no evidence of GVHD. Haploidentical HSCTs as primary or secondary sources of stem cells, with appropriate T-cell depletion, may be a readily available option in the absence of HLA-matched related or unrelated donors. Pediatr Blood Cancer 2010;55:580-582 (C) 2010 Wiley-Liss, Inc.
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