Journal
PEDIATRIC BLOOD & CANCER
Volume 56, Issue 3, Pages 470-473Publisher
WILEY-LISS
DOI: 10.1002/pbc.22909
Keywords
22q11.21 duplication syndrome; acute lymphoblastic leukemia; cystinuria; microarray chromosome analysis
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Duplication 22q11.2 syndrome is the result of a microduplication of the same chromosomal region that is deleted in DiGeorge and Velocardiofacial syndromes. We describe a patient with dysmorphic features who was diagnosed with pre-B acute lymphoblastic leukemia, and developed cystinuria and pancreatitis during treatment. Duplication 22q11.2 has not been previously described in association with hematologic abnormalities. Chromosomal microarray technology was used to diagnose duplication 22q11.2 syndrome. In this era of advanced genomics, this technology has become an important method for helping to determine the molecular basis of diseases, best treatments and ultimately patient outcomes. Pediatr Blood Cancer 2011;56:470-473. (C) 2010 Wiley-Liss, Inc.
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